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EU Amends REACH Regulation, Adds 16 New CMR Substances

from CIRS by

On August 11, 2025, the European Commission formally adopted Commission Regulation (EU) 2025/1731, amending Annex XVII of the Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH) Regulation to strengthen controls over Carcinogenic, Mutagenic, or Reproductive Toxic (CMR) substances.

Key Amendments

The following 16 CMR substances have been added to REACH Annex XVII:

Substances

EC No

CAS No

Hazard Classification

‘diuron (ISO); 3-(3,4-dichlorophenyl)-1,1-dimethylurea

206-354-4

330-54-1

Carcinogen Category 1B

‘2,2',6,6'-tetrabromo-4,4'-isopropylidenediphenol; tetrabromobisphenol-A

201-236-9

79-94-7

Carcinogen Category 1B

‘N,N-dimethyl-p-toluidine

202-805-4

99-97-8

Carcinogen Category 1B

‘4-nitrosomorpholine

-

59-89-2

Carcinogen Category 1B

‘4-methylimidazole

212-497-3

822-36-6

Carcinogen Category 1B, Reproductive Toxicity Category 1B

‘dimethyl propylphosphonate

242-555-3

18755-43-6

Mutagen Category 1B, Reproductive Toxicity Category 1B

‘diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide

278-355-8

75980-60-8

Reproductive Toxicity Category 1B

‘benzyl(diethylamino)diphenylphosphonium 4-[1,1,1,3,3,3-hexafluoro-2-(4-hydroxyphenyl)propan-2-yl]phenolate

479-100-5

577705-90-9

Reproductive Toxicity Category 1B

‘benzyltriphenylphosphonium, salt with 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis[phenol] (1:1)

278-305-5

75768-65-9

Reproductive Toxicity Category 1B

‘reaction mass of 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol and benzyl(diethylamino)diphenylphosphonium 4-[1,1,1,3,3,3-hexafluoro-2-(4-hydroxyphenyl)propan-2-yl]phenolate (1:1)

-

-

Reproductive Toxicity Category 1B

‘reaction mass of 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol and benzyltriphenylphosphonium, salt with 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol (1:1)

-

-

Reproductive Toxicity Category 1B

‘dibutyltin maleate

201-077-5

78-04-6

Reproductive Toxicity Category 1B

‘dibutyltin oxide

212-449-1

818-08-6

Reproductive Toxicity Category 1B

‘reaction mass of 1-(2,3-epoxypropoxy)-2,2-bis ((2,3-epoxypropoxy)methyl) butane and 1-(2,3-epoxypropoxy)-2-((2,3-epoxypropoxy)methyl)-2-hydroxymethyl butane

-

-

Reproductive Toxicity Category 1B

‘4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphenol; bisphenol AF

216-036-7

1478-61-1

Reproductive Toxicity Category 1B

‘1,4-Benzenediamine, N,N’-mixed Ph and tolyl derivs.;

273-227-8

68953-84-4

Reproductive Toxicity Category 1B

Derogations

Substances

CAS No

 

EC No

Derogations

Cumene

 98-82-8

202-704-5

As a substance on its own or as a constituent of other substances in either of the following:

(a)   kerosene used as aviation fuel conforming to DEF STAN 91-091, ASTM specification D1655 or equivalent recognised standards and marketed under descriptions such as Jet-A, Jet-A1 or JP-(x);

(b) gasoline used as aviation fuel conforming to DEF STAN 91-090, ASTM D910, ASTM D7547 or equivalent recognised standards.

Regulatory Timeline

Restrictions on the new Category 1B CMR substances will officially take effect on September 1, 2025, and apply directly across all EU member states.

If you need any assistance or have any questions, please get in touch with us via service@cirs-group.com.

Further Information

Official Journal

 

  

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