On October 15, 2026, the European Union’s Scientific Committee on Consumer Safety (SCCS) published its final opinion (SCCS/1688/26) regarding the safety of Heliotropin (CAS No. 120-57-0, EC No. 204-409-7) in cosmetic products. This final version updates the preliminary opinion issued on April 15, 2026.
Summary of the Final Opinion on Heliotropin
Based on the assessment of data provided and taking into consideration the concerns related to the possible classification as Repr.1B under Regulation (EC) No 1272/2008 (CLP), the SCCS considers Heliotropin safe when used up to the maximum concentration of 1.8% only in fine fragrances for adults.
This SCCS assessment only covers the use of heliotropin in fine fragrances for adults as mandated. However, the SCCS noted that the Applicant provided MoS calculations for other cosmetic products (including for children), suggesting that their (aggregated) use would be within the margin of safety.
The SCCS also noticed that some non-nicotine liquids for e-cigarettes may contain Heliotropin, which, depending on national legislation, may be covered under different regulatory frameworks. The Applicant provided MoS calculations for tobacco products and e-cigarettes, suggesting that the aggregated exposure with cosmetic products would be within the margin of safety.
Assessment Background
Heliotropin (CAS No. 120-57-0, EC No. 204-409-7), also known as piperonal, is an aromatic compound commonly used in cosmetic products for its sweet, floral scent. Naturally found in some essential oils but mostly produced synthetically, Heliotropin is a popular fragrance ingredient in perfumes, lotions, creams, shampoos, and deodorants. In addition, Heliotropin can function as a fixative, helping to stabilize and prolong other scents in a formulation, as well as a masking agent, softening the odour of other ingredients to enhance overall product appeal.
In September 2024, ECHA's RAC recommended classifying Heliotropin as Reprotoxic Category 1B (H360Fd), which could lead to its inclusion in CLP Annex VI. Under Article 15(2) of the Cosmetics Regulation, CMR 1A/1B substances are prohibited in cosmetics unless specific exemption conditions are met. In June 2025, the European Commission has accordingly requested the SCCS to conduct a safety assessment.
Global Regulatory Status
According to Global CosIng, independently developed by CIRS Group, Heliotropin (CAS No. 120-57-0) is included in the following lists globally. In China, Heliotropin has been included in the Inventory of Existing Cosmetic Ingredients in China I (IECIC I).
What Can CIRS Do for You
Established in 2007, the CIRS Group is a leading product safety and regulatory consulting firm. CIRS has branch offices in the Republic of Ireland, South Korea, the United States, the United Kingdom, Japan, and China. CIRS Group utilizes its technical expertise, various resources, and international network to provide one-stop compliance services, from regulatory compliance, laboratory testing, and R&D to data services across multiple industries. This includes chemicals, cosmetics, food and food beverages, medical devices, agrochemical products, disinfectants, and consumer goods. It helps clients gain a competitive advantage by reducing business risks associated with regulatory affairs.
The CIRS cosmetic team provides expert support to ensure that cosmetic products meet stringent global cosmetic regulations and safety standards.
We offer comprehensive, lifecycle-based solutions for personal care products, from early-stage cosmetic ingredient development through to final product registration. Our services include:
- Cosmetic ingredient development and regulatory strategy,
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- Ingredient and product registration across global markets.
With deep expertise in cosmetic regulatory compliance and safety evaluations, our team enables brands to bring products to market efficiently and with confidence.
Our Services
- EU Cosmetic Product Formula and Label Review
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- Product Information File (PIF)
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