On 25 October, 2024, the Scientific Committee on Consumer Safety (SCCS) of the European Union issued the final opinion (SCCS/1663/24) on the inhalation toxicity of the fragrance ingredient acetylated vetiver oil-AVO (CAS No.84082-84-8, EC No.282-031-1) in sprayable cosmetic products. The preliminary opinion was issued on 5 March, 2024.
The SCCS concludes the following:
Having considered the data provided concerning inhalation toxicity and aggregate exposure, the SCCS considers Acetylated Vetiver Oil (AVO) (with 1% alpha-tocopherol) safe when used at the intended maximum concentrations (IMCs) of 0.9% (w/w) in fragrance pump sprays, 0.05% (w/w) in deodorant sprays and 0.1% (w/w) in hairsprays and body lotion sprays. The findings of an in vitro study using Mucilair™ also support this conclusion.
The Chinese Cosmetic Ingredient Regulatory Database (ChinaCosIng), independently developed by CIRS Group, indicates that Acetylated Vetiver Oil (AVO) is not yet included in the "Inventory of Existing Cosmetic Ingredients in China" (IECIC) (2021 edition).
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