China NHC issued notifications regarding the acceptance of “three new foods”. The applications for 10 new food materials, 21 new food additives and 1 new food-related products have been received.

Recently, Enhe Aiju (Hangzhou) Science and Technology Co., Ltd. (Enhe Aiju) has completed the FDA GRAS notice for its self-developed zeaxanthin, produced via fermentation using production strain Yarrowia lipolytica CGMCC 39021 (GRN No. 1300). This is the world’s first high-concentration crystalline zeaxanthin product manufactured at commercial scale using cell factory technology to receive GRAS, fully under the support of CIRS Group.

On May 27, 2026, National Health Commission of the People’s Republic of China (NHC) issued an announcement (No. 2 of 2026) for “Three New Foods” with 16 products approved, including 7 new food raw materials and 7 new food additives.

Recently, the European Commission’s novel food status has updated the information regarding S-adenosyl-L-methionine disulfate tosylate (also referred to as Sadenosyl-L-methionine disulfate p-toluenesulfonate). According to the latest novel food status, this ingredient has now been recognized as a novel food.

In the US, products similar to health foods are referred to as dietary supplements. Compared to health foods in China, there are significant differences in the naming, marketing requirements in America. To help companies better understand the compliance requirements for dietary supplements in the US, CIRS Group has summarized the relevant regulations for reference.

The U.S. New Dietary Ingredient (NDI) database was updated on May 8, with a total of 27 substances having their status updated. CIRS has organized the updated data for you. It should be noted that there is a lag in the NDI database updates. The latest FDA response times in this update report are all earlier than December 18, 2025. Currently, the actual number of completed NDI notifications is actually greater than the data currently published on the official website. CIRS Group will continue to pay close attention to subsequent updates on the FDA official website.

The food enzyme amidase (acylamide amidohydrolase, EC 3.5.1.4) is produced with the genetically modified Escherichia coli strain SP-a by c-LEcta GmbH. The genetic modifications did not give rise to safety concerns.

To help companies clearly understand the international compliance status of NMN, CIRS Group will summarize the application approval status of NMN in the EU, the US, and Australia for reference.

The New York State Assembly passed the Food Safety and Chemical Disclosure Act (Bill No. S1239F/A1556G) on April 21, which has now been sent to Governor for signature. If the governor officially signs it, this will be the first state law in the United States requiring businesses to publicly disclose safety evidence for self-GRAS substances to the state government.

To sell dietary supplements containing new dietary ingredients (NDI) in the U.S. market, you must submit an NDI notification (NDIN) to the FDA at least 75 days in advance. However, the FDA’s response to an NDIN does not have a clear conclusion like a GRAS notice, such as “FDA has no questions”. As a result, many companies often find it difficult to determine whether their notification has been “notified” when faced with a response filled with regulatory clauses and template terminology. CIRS Group combines FDA official guidelines and real cases to break down the types of NDIN responses and interpret the notification results for your reference.