The restricted substances include lead, mercury, cadmium, hexavalent chromium, polybrominated biphenyls (PBB), polybrominated diphenyl ethers (PBDE), and four phthalates.

On May 13, 2025, Brazil’s Ministry of the Environment and Climate Change (MMA) published a draft implementing regulation for the Chemical Management Law (Brazil REACH), aimed at operationalizing Law No. 15,022 of November 13, 2024. The draft establishes a National Inventory of Chemical Substances to regulate the registration, hazard identification, assessment, and management of chemicals, with the goal of reducing health and environmental risks.

Brazil's updated GHS national standard ABNT NBR 14725:2023, released by the Brazilian Technical Standards Association (ABNT) on July 3, 2023, will officially take effect on July 4, 2025. This comprehensive analysis outlines three key operational requirements for enterprises to ensure SDS and GHS label compliance.

On November 15, 2024, Brazilian Chemical Management Law No. 15. 022 (also known as Brazil REACH) officially came into effect, marking a significant step forward in the field of chemical regulations in Brazil. According to the provisions of this regulation, manufacturers and importers must complete registration in a newly established registration system for non-exempt chemicals with an annual production or import volume exceeding one ton, with the aim to prioritize the identification and focus on chemicals, conduct risk assessments, and ultimately implement risk management measures.

The Global Chemical Inventory Search (GCIS) developed by CIRS Group supports users to search the latest inventory of chemicals globally by entering CAS number or substance name in both Chinese and English. It also provides obligation analysis for global chemical compliance. CIRS continuously monitors and updates to global chemical inventories regularly, trying to help users to know more details of compliance obligations of their substances.

On October 15, 2024, Brazil's Senate approved Bill No. 6120 of 2019, a REACH-like chemical management bill aimed at establishing a national registry of chemical substances. This bill mandates a comprehensive assessment and risk control of chemicals used, produced, or imported within the country to minimize adverse impacts on human health and the environment.

On September 26, 2023, the Commission on Constitution, Justice and Citizenship (CCJC) in Brazil published PL 6120/2019. Eariler on May 9, 2023, CCJC approved the bill (PL 6120/2019) and has send it to the Federal Senate for further consideration. PL 6120/2019 proposes to set up a national chemical inventory as a national database to collect the information on chemicals imported or manufactured in Brazil with hazard characteristics. If PL 6120/2019 is approved, Brazil will be the fourth country in South America that have chemical management regulations, following Peru, Chile, and Colombia.

Earlier in 2019, PL 6120/2019 was submitted to establish a national inventory of chemicals and collect information of chemicals manufactured in or imported to Brazil. However, substantial progress was not made. Currently, the bill has been transferred to the Federal Senate for further approval. If the bill successfully passes and becomes a law, Brazil will adopt a national chemical inventory system which covers official assessment of substance risks, the publication of authorized substance lists, and the clarification of enforcement agencies.

On November 23, 2022, Bill PL 6120/2019 was approved by the Commission of Economic Development, Industry, Trade, and Commercial Services (CDEICS) of the Brazilian Chamber of Deputies and has been submitted to the Commission on Constitution, Justice and Citizenship (CCJS) for further review. If the Bill successfully passes the review, it will act as the Brazilian REACH Regulation. Domestic enterprises involved in exporting chemicals to Brazil should pay close attention to the Bill. If the Bill becomes law, Brazil will become the third country in South America, to set up chemical management rules, after Chile and Colombia.