China's CFSA Collects Public Comments on Seven New Food Additives including Glucose isomerase, LNT, LNnT, 2’-FL

China,Food,Additive,Public,Comments

On September 29, 2025, China National Center for Food Safety Risk Assessment (CFSA) issued seven new food additives for public comments, including:

two new enzymes,
one new food spice,
one new food nutrition enhancer,
one food additive with expanded scope, and
two food additives with additional requirements for quality specifications.

Comments are welcomed before October 29, 2025. Details are as follows:

New enzyme preparations for the food industry (two types)

Enzyme

Source

Donor

Sucrose

1-fructosyltransferase

Aspergillus japonicus

Glucose isomerase

(xylose isomerase)

Bacillus subtilis 168-N03

Streptomycis murinus

The quality specification requirements of enzyme preparations for food industry should be in accordance with the provisions of National Standard for Food Safety Food Additives Enzyme Preparations for Food Industry (GB 1886.174).

New food spice (one type)

2-methyl-1-(2-(5-(p-tolyl)-1H-imidazol-2-yl) piperidin-1-yl) butan-1-one

Applicable scope and maximum levels:

Food name	Maximum level （g/Kg）	Remark
For use in compounded food flavorings applicable to all foods except those excluded under GB 2760, Table B.1.	Use as needed in the manufacturing process.	—

These quality specification requirements apply to the food additive 2-Methyl-1-[2-(5-(p-tolyl)-1H-imidazol-2-yl)piperidin-1-yl]butan-1-one, which is produced by a chemical reaction using piperidic acid and 2-methylbutanoyl chloride as raw materials.

New food nutrition enhancers (one type)

Lacto-N-tetraose, LNT

The quality specification requirements for Lacto-N-tetraose (LNT) shall comply with the provisions outlined in China CFSA Collects Public Comments on Eight New Food Additives, including Aminopeptidase, 3-FL, LNT, under the section concerning the nutritional fortifier Lacto-N-tetraose, excluding the production strain information specified in Appendix C for Lacto-N-tetraose. The information on the production strain used for this new nutritional fortifier variety is provided in the table below.

Name

Source

Donor

Lacto-N-tetraose, LNT

Escherichia coli

BL21 (DE3)

Neisseriameningitidis and

Citrobacter

meridianamericanus

Food additives with expanded scope (one type)

S.N.

Name

Category number

Food name

Maximum level （g/Kg）

Remark

Carbon Dioxide (CO₂)

14.01.02

Drinking purified water

Use as needed in the manufacturing process.

14.01.03

Other types of drinking water

Food additives with additional requirements for quality specifications (two types)

Nutrition enhancer — 2’-Fucosyllactose

The quality specification requirements for this substance shall be implemented in accordance with the National Health Commission Announcement No. 8 of 2023 (excluding the production microorganism information for 2’-fucosyllactose in Appendix C). The production microorganism information for this new nutritional fortifier is listed in the table below.

Name	Source	Donor
2’-fucosyllactose	Escherichia coli K-12 MG1655	Helicobacter spp.

Nutrition enhancer —Lacto-N-neotetraose

The quality specification requirements for this substance shall be implemented in accordance with the National Health Commission Announcement No. 8 of 2023 (excluding the production microorganism information for Lacto-N-neotetraose in Appendix D). The production microorganism information for this new nutritional fortifier is listed in the table below.

Name

Source

Donor

Lacto-N-neotetraose

Escherichia coli BL21(DE3)

Neisseriameningitidis and

Aggregatibacter kilianii

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